Ontology highlight
ABSTRACT:
SUBMITTER: Temel RE
PROVIDER: S-EPMC2913877 | biostudies-other | 2010 Jul
REPOSITORIES: biostudies-other
Temel Ryan E RE Sawyer Janet K JK Yu Liqing L Lord Caleb C Degirolamo Chiara C McDaniel Allison A Marshall Stephanie S Wang Nanping N Shah Ramesh R Rudel Lawrence L LL Brown J Mark JM
Cell metabolism 20100701 1
Recent evidence suggests that the intestine may play a direct facilitative role in reverse cholesterol transport (RCT), independent of hepatobiliary secretion. In order to understand the nonbiliary pathway for RCT, we created both genetic and surgical models of biliary cholesterol insufficiency. To genetically inhibit biliary cholesterol secretion, we generated mice in which Niemann-Pick C1-Like 1 (NPC1L1) was overexpressed in the liver. Compared to controls, NPC1L1(Liver-Tg) mice exhibit a >90% ...[more]