Ontology highlight
ABSTRACT:
SUBMITTER: Fu D
PROVIDER: S-EPMC2917595 | biostudies-other | 2007 Dec
REPOSITORIES: biostudies-other
Fu Dragony D Collins Kathleen K
Molecular cell 20071201 5
The identities and roles of proteins associated with human telomerase remain poorly defined. To gain insight, we undertook an affinity purification of endogenously assembled human telomerase complexes. We show that specific subsets of H/ACA, Sm, and hnRNP proteins associate with active and inactive telomerase RNPs, while two NTPase proteins associate preferentially with active enzyme. All three core H/ACA-motif binding proteins are telomerase holoenzyme components essential for RNP accumulation. ...[more]