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RAFT polymers for protein recognition.

ABSTRACT: A new family of linear polymers with pronounced affinity for arginine- and lysine-rich proteins has been created. To this end, N-isopropylacrylamide (NIPAM) was copolymerized in water with a binding monomer and a hydrophobic comonomer using a living radical polymerization (RAFT). The resulting copolymers were water-soluble and displayed narrow polydispersities. They formed tight complexes with basic proteins depending on the nature and amount of the binding monomer as well as on the choice of the added hydrophobic comonomer.

SUBMITTER: Tominey AF

PROVIDER: S-EPMC2919265 | biostudies-other | 2010

REPOSITORIES: biostudies-other

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RAFT polymers for protein recognition.

Tominey Alan F AF Liese Julia J Wei Sun S Kowski Klaus K Schrader Thomas T Kraft Arno A

Beilstein journal of organic chemistry 20100617

A new family of linear polymers with pronounced affinity for arginine- and lysine-rich proteins has been created. To this end, N-isopropylacrylamide (NIPAM) was copolymerized in water with a binding monomer and a hydrophobic comonomer using a living radical polymerization (RAFT). The resulting copolymers were water-soluble and displayed narrow polydispersities. They formed tight complexes with basic proteins depending on the nature and amount of the binding monomer as well as on the choice of th ...[more]

PMID: 20703378

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