Ontology highlight
ABSTRACT:
SUBMITTER: Trzupek JD
PROVIDER: S-EPMC2920150 | biostudies-other | 2010 Apr
REPOSITORIES: biostudies-other
Pure and applied chemistry. Chimie pure et appliquee 20100401 9
The furanobisindole alkaloid, phalarine, possesses a unique structural framework within the alkaloid family of natural products. Our laboratory recently disclosed the racemic total synthesis of phalarine, featuring an efficient azaspiroindolenine rearrangement; this achievement is revisited in detail. Upon completion of the first-generation total synthesis, we explored some interesting mechanism-level issues with regard to the key azaspiroindolenine rearrangement. These investigations provided v ...[more]