Ontology highlight
ABSTRACT:
SUBMITTER: Rodriguez N
PROVIDER: S-EPMC2920645 | biostudies-other | 2010 Aug
REPOSITORIES: biostudies-other
Rodriguez Nicolas N Amarouch Mohamed Yassine MY Montnach Jérôme J Piron Julien J Labro Alain J AJ Charpentier Flavien F Mérot Jean J Baró Isabelle I Loussouarn Gildas G
Biophysical journal 20100801 4
Phosphatidylinositol-4,5-bisphosphate (PIP(2)) is a phospholipid that has been shown to modulate several ion channels, including some voltage-gated channels like Kv11.1 (hERG). From a biophysical perspective, the mechanisms underlying this regulation are not well characterized. From a physiological perspective, it is critical to establish whether the PIP(2) effect is within the physiological concentration range. Using the giant-patch configuration of the patch-clamp technique on COS-7 cells expr ...[more]