Supramolecular insulin assembly II for a sustained treatment of type 1 diabetes mellitus.
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ABSTRACT:
SUBMITTER: Gupta S
PROVIDER: S-EPMC2922159 | biostudies-other | 2010 Jul
REPOSITORIES: biostudies-other
Publications
Supramolecular insulin assembly II for a sustained treatment of type 1 diabetes mellitus.
Gupta Sarika S Chattopadhyay Tandrika T Pal Singh Mahendra M Surolia Avadhesha A
Proceedings of the National Academy of Sciences of the United States of America 20100713 30
Diabetes is a chronic disease requiring continuous medical supervision and patient education to prevent acute secondary complications. In this study, we have harnessed the inherent property of insulin to aggregate into an oligomeric intermediate on the pathway to amyloid formation, to generate a form that exhibits controlled and sustained release for extended periods. Administration of a single dose of the insulin oligomer, defined here as the supramolecular insulin assembly II (SIA-II), to expe ...[more]
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