The endocannabinoid system links gut microbiota to adipogenesis.
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ABSTRACT:
SUBMITTER: Muccioli GG
PROVIDER: S-EPMC2925525 | biostudies-other | 2010 Jul
REPOSITORIES: biostudies-other
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The endocannabinoid system links gut microbiota to adipogenesis.
Muccioli Giulio G GG Naslain Damien D Bäckhed Fredrik F Reigstad Christopher S CS Lambert Didier M DM Delzenne Nathalie M NM Cani Patrice D PD
Molecular systems biology 20100701
Obesity is characterised by altered gut microbiota, low-grade inflammation and increased endocannabinoid (eCB) system tone; however, a clear connection between gut microbiota and eCB signalling has yet to be confirmed. Here, we report that gut microbiota modulate the intestinal eCB system tone, which in turn regulates gut permeability and plasma lipopolysaccharide (LPS) levels. The impact of the increased plasma LPS levels and eCB system tone found in obesity on adipose tissue metabolism (e.g. d ...[more]
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