Ontology highlight
ABSTRACT:
SUBMITTER: Kohler ME
PROVIDER: S-EPMC2935508 | biostudies-other | 2010
REPOSITORIES: biostudies-other
Kohler M Eric ME Hallett William H D WH Chen Qing-Rong QR Khan Javed J Johnson Bryon D BD Orentas Rimas J RJ
Cellular immunology 20100717 1
Using a mouse neuroblastoma cell line, we have demonstrated that vaccination of tumor-free mice with a cell-based vaccine leads to productive immunity and resistance to tumor challenge, while vaccination of tumor-bearing mice does not. The T cell immunity induced by this vaccine, as measured by in vitro assays, is amplified by the depletion of Treg. Our goal is to understand this barrier to the development of protective cellular immunity. mRNA microarray analyses of CD8(+) T cells from naïve or ...[more]