Ontology highlight
ABSTRACT:
SUBMITTER: Keller RL
PROVIDER: S-EPMC2937245 | biostudies-other | 2010 Aug
REPOSITORIES: biostudies-other
Keller Roberta L RL Tacy Theresa A TA Hendricks-Munoz Karen K Xu Jie J Moon-Grady Anita J AJ Neuhaus John J Moore Phillip P Nobuhara Kerilyn K KK Hawgood Sam S Fineman Jeffrey R JR
American journal of respiratory and critical care medicine 20100422 4
<h4>Rationale</h4>Endothelin-1 (ET1) is dysregulated in pulmonary hypertension (PH). It may be important in the pathobiology of congenital diaphragmatic hernia (CDH).<h4>Objectives</h4>We hypothesized that ET1 levels in the first month would be higher in infants with CDH who subsequently expired or were discharged on oxygen (poor outcome). We further hypothesized that ET1 levels would be associated with concurrent severity of PH.<h4>Methods</h4>We sampled plasma at 24 to 48 hours, and 1, 2, and ...[more]