Ontology highlight
ABSTRACT:
SUBMITTER: Coombs GS
PROVIDER: S-EPMC2939803 | biostudies-other | 2010 Oct
REPOSITORIES: biostudies-other
Coombs Gary S GS Yu Jia J Canning Claire A CA Veltri Charles A CA Covey Tracy M TM Cheong Jit K JK Utomo Velani V Banerjee Nikhil N Zhang Zong Hong ZH Jadulco Raquel C RC Concepcion Gisela P GP Bugni Tim S TS Harper Mary Kay MK Mihalek Ivana I Jones C Michael CM Ireland Chris M CM Virshup David M DM
Journal of cell science 20100907 Pt 19
Wnt proteins are secreted post-translationally modified proteins that signal locally to regulate development and proliferation. The production of bioactive Wnts requires a number of dedicated factors in the secreting cell whose coordinated functions are not fully understood. A screen for small molecules identified inhibitors of vacuolar acidification as potent inhibitors of Wnt secretion. Inhibition of the V-ATPase or disruption of vacuolar pH gradients by diverse drugs potently inhibited Wnt/β- ...[more]