Ontology highlight
ABSTRACT:
SUBMITTER: Recober A
PROVIDER: S-EPMC2944225 | biostudies-other | 2009 Jul
REPOSITORIES: biostudies-other
Recober Ana A Kuburas Adisa A Zhang Zhongming Z Wemmie John A JA Anderson Michael G MG Russo Andrew F AF
The Journal of neuroscience : the official journal of the Society for Neuroscience 20090701 27
Migraine is a chronic neurological disorder characterized by recurrent episodes of severe unilateral throbbing head pain and associated symptoms, such as photophobia. Our current understanding of the mechanisms underlying migraine has been hampered by limitations in ascertaining migraine symptoms in animal models. Clinical studies have established the neuropeptide calcitonin gene-related peptide (CGRP) as a key player in migraine. Here, we establish a genetic model of photophobia by engineering ...[more]