Ontology highlight
ABSTRACT:
SUBMITTER: Alcazar I
PROVIDER: S-EPMC2945823 | biostudies-other | 2009 Apr
REPOSITORIES: biostudies-other
Alcázar Isabela I Cortés Isabel I Zaballos Angel A Hernandez Carmen C Fruman David A DA Barber Domingo F DF Carrera Ana C AC
Blood 20090203 14
CD28 is a receptor expressed on T cells that regulates their differentiation after antigen stimulation to long-term-survival memory T cells. CD28 enhances T-cell receptor signals and reduces expression of CBL ubiquitin ligases, which negatively control T-cell activation. In the absence of CD28 ligation during the primary stimulation, CBL levels remain high and T cells fail to mount an efficient secondary response. CD28 associates with p85alpha, one of the regulatory subunits of phosphoinositide- ...[more]