Ontology highlight
ABSTRACT:
SUBMITTER: Schweitzer BA
PROVIDER: S-EPMC2946157 | biostudies-other | 1994 Dec
REPOSITORIES: biostudies-other
The Journal of organic chemistry 19941201 24
Described are the design, synthesis, and structures of three nonpolar nucleoside isosteres to be used as probes of noncovalent bonding in DNA and as isosteric replacements for the natural nucleosides in designed nucleic acid structures. Reaction of substituted aryl Grignards with 3',5'-bis-O-toluoyl-α-deoxyibofuranosyl chloride and subsequent deprotection with sodium methoxide in methanol afforded the two β-C-nucleoside pyrimidine analogs 1 and 2. The dimethylindolyl nucleoside 3, a purine isost ...[more]