Ontology highlight
ABSTRACT:
SUBMITTER: Lambe T
PROVIDER: S-EPMC2947353 | biostudies-other | 2009 Feb
REPOSITORIES: biostudies-other
Lambe Teresa T Simpson Robert J RJ Dawson Sara S Bouriez-Jones Tiphaine T Crockford Tanya L TL Lepherd Michelle M Latunde-Dada Gladys O GO Robinson Hannah H Raja Kishor B KB Campagna Dean R DR Villarreal Guadalupe G Ellory J Clive JC Goodnow Christopher C CC Fleming Mark D MD McKie Andrew T AT Cornall Richard J RJ
Blood 20081027 8
Hereditary forms of iron-deficiency anemia, including animal models, have taught us much about the normal physiologic control of iron metabolism. However, the discovery of new informative mutants is limited by the natural mutation frequency. To address this limitation, we have developed a screen for heritable abnormalities of red blood cell morphology in mice with single-nucleotide changes induced by the chemical mutagen ethylnitrosourea (ENU). We now describe the first strain, fragile-red, with ...[more]