Ontology highlight
ABSTRACT:
SUBMITTER: Kuczynski J
PROVIDER: S-EPMC2948603 | biostudies-other | 2010 Oct
REPOSITORIES: biostudies-other
Kuczynski Justin J Liu Zongzhi Z Lozupone Catherine C McDonald Daniel D Fierer Noah N Knight Rob R
Nature methods 20100905 10
High-throughput sequencing methods enable characterization of microbial communities in a wide range of environments on an unprecedented scale. However, insight into microbial community composition is limited by our ability to detect patterns in this flood of sequences. Here we compare the performance of 51 analysis techniques using real and simulated bacterial 16S rRNA pyrosequencing datasets containing either clustered samples or samples arrayed across environmental gradients. We found that man ...[more]