Ontology highlight
ABSTRACT:
SUBMITTER: Homayoun H
PROVIDER: S-EPMC2954603 | biostudies-other | 2007 Oct
REPOSITORIES: biostudies-other
Homayoun Houman H Moghaddam Bita B
The Journal of neuroscience : the official journal of the Society for Neuroscience 20071001 43
NMDA receptors mediate excitatory postsynaptic potentials throughout the brain but, paradoxically, NMDA receptor antagonists produce cortical excitation in humans and behaving rodents. To elucidate a mechanism for these diverging effects, we examined the effect of use-dependent inhibition of NMDA receptors on the spontaneous activity of putative GABA interneurons and pyramidal neurons in the prefrontal cortex of awake rats. We find that inhibition of NMDA receptors predominately decreases the ac ...[more]