BRAF p.Val600Glu (V600E) Testing for Assessment of Treatment Options in Metastatic Colorectal Cancer.
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ABSTRACT:
SUBMITTER: Lea A
PROVIDER: S-EPMC2957244 | biostudies-other | 2010 Oct
REPOSITORIES: biostudies-other
Publications
BRAF p.Val600Glu (V600E) Testing for Assessment of Treatment Options in Metastatic Colorectal Cancer.
Lea Andrew A Allingham-Hawkins Diane D Levine Susan S
PLoS currents 20101019
Colon and rectal cancer (CRC) are the third most common cancer in the United States and cause approximately 50,000 deaths per year. The anti-epidermal growth factor receptor (EGFR) monoclonal antibodies cetuximab (Erbitux®) and panitumumab (Vectibix®) have been recently introduced to treat CRC. However, the response rate with these agents is low and they are associated with serious adverse effects. Accordingly biomarkers that can predict those patients that will respond to treatment may have cli ...[more]
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