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Detailed analysis of the CD8+ T-cell response following adenovirus vaccination.


ABSTRACT: We examined CD8(+) T-cell expansion and function following intramuscular immunization with a recombinant adenovirus. This study has identified a number of properties which may explain the strong immunogenicity of adenovirus vectors: (i) the ability to deliver large amounts of antigen into the lymphoid tissues, (ii) the ability to induce rapid expansion and migration of CD8(+) T cells throughout the lymphatics, and (iii) the ability to produce a sustained, high-level CD8(+) T-cell response.

SUBMITTER: Yang TC 

PROVIDER: S-EPMC296052 | biostudies-other | 2003 Dec

REPOSITORIES: biostudies-other

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