Risk of breast cancer according to clinicopathologic features among long-term survivors of Hodgkin's lymphoma treated with radiotherapy.
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ABSTRACT: It is unknown whether breast cancer (BC) characteristics among young women treated with radiotherapy (RT) for Hodgkin's lymphoma (HL) differ from sporadic BC.Using population-based data, we calculated BC risk following HL according to clinicopathologic features.Compared with BC in the general population, risks of oestrogen receptor (ER)-positive/progesterone receptor (PR)-positive and ER-negative/PR-negative BC in young, irradiated HL survivors were increased five-fold (95% confidence interval (CI)=3.81-6.35) and nine-fold (95% CI=6.93-12.25), respectively. Among 15-year survivors, relative risk of ER-negative/PR-negative BC exceeded by two-fold (P=0.002) than that of ER-positive/PR-positive BC.Radiotherapy may disproportionately contribute to the development of BC with adverse prognostic features among young HL survivors.
SUBMITTER: Dores GM
PROVIDER: S-EPMC2965878 | biostudies-other | 2010 Sep
REPOSITORIES: biostudies-other
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