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1-(2-Chloro-acet-yl)-3-methyl-2,6-diphenyl-piperidin-4-one.

ABSTRACT: The asymmetric unit of the title compound, C(20)H(20)ClNO(2), contains two crystallographically independent mol-ecules of similar geometry. The piperidine ring adopts a distorted boat conformation in both mol-ecules, in which the N atom assumes an almost planar configuration.

SUBMITTER: Khan FN

PROVIDER: S-EPMC2971901 | biostudies-other | 2009

REPOSITORIES: biostudies-other

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1-(2-Chloro-acet-yl)-3-methyl-2,6-diphenyl-piperidin-4-one.

Khan F Nawaz FN Nithya P P Krishna Kumar V V Hathwar Venkatesha R VR Ng Seik Weng SW

Acta crystallographica. Section E, Structure reports online 20091104 Pt 12

The asymmetric unit of the title compound, C(20)H(20)ClNO(2), contains two crystallographically independent mol-ecules of similar geometry. The piperidine ring adopts a distorted boat conformation in both mol-ecules, in which the N atom assumes an almost planar configuration. ...[more]

PMID: 21578725

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1-(2-Azido-acet-yl)-3-methyl-2,6-diphenyl-piperidin-4-one.

Project description:In the title compound, C(20)H(20)N(4)O(2), the piperidine ring adopts a distorted boat conformation. The two phenyl rings form dihedral angles of 82.87?(1) and 84.40?(1)° with respect to the piperidine ring. The crystal packing is stabilized by inter-molecular C-H?O and C-H?N inter-actions.

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1-(2-Bromo-acet-yl)-3-methyl-2,6-diphenyl-piperidin-4-one.

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Crystal structure of 1-(2-chloro-acet-yl)-2,6-bis-(4-fluoro-phen-yl)-3,3-di-methyl-piperidin-4-one.

Project description:In the title mol-ecule, C21H20ClF2NO2, the piperidine ring adopts a slightly distorted boat conformation. The two benzene rings form a dihedral angle of 87.43?(1)°. A weak intra-molecular C-H?? inter-action is observed. In the crystal, weak C-H?O hydrogen bonds and weak C-H?? inter-actions connect the mol-ecules, forming a three-dimensional network.

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Crystal structure of 1-(2-chloro-acet-yl)-3,3-dimethyl-2,6-di-p-tolyl-piperidin-4-one.

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1-(2,2-Di-chloro-acet-yl)-3-ethyl-2,6-di-phenyl-piperidin-4-one.

Project description:The asymmetric unit of the title compound, C21H21Cl2NO2, contains two independent mol-ecules that show similar geometrical features. The piperidine ring adopts a distorted boat conformation. The phenyl rings substituted at the 2- and 6-positions of the piperidine ring are oriented at angles of 65.4?(1) [64.7?(2)°] and 89.2?(1)° [86.3?(2)°] with respect to the least-squares plane of the piperidine ring. In the crystal, adjacent mol-ecules are linked by a network of C-H?O inter-actions, forming a C(6) chain along the c-axis direction.

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3-Isopropyl-1-{2-[(1-methyl-1H-tetra-zol-5-yl)sulfan-yl]acet-yl}-2,6-di-phenyl-piperidin-4-one hemihydrate.

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Project description:In the title compound, C(21)H(20)Cl(3)NO(2), the piperidin-4-one ring adopts a boat conformation. The two 2-chloro-phenyl groups are approximately perpendicular to each other, making a dihedral angle of 74.07 (8)°.

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Project description:In the title compound, C29H32N2O2, the piperidine ring exists in a chair conformation (the bond-angle sum at the sp (2)-hybridized C atom is 359.79°). The phenyl rings and the methyl group substituted on the heterocyclic ring are in equatorial orientations. In the crystal, pairs of C-H?? inter-actions result in the formation of inversion dimers.

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1-Chloro-acetyl-2,6-bis-(3-fluoro-phen-yl)piperidin-4-one.

Project description:In the title compound C(19)H(16)ClF(2)NO(2), the piperidone ring adopts a twist-boat conformation with the two out-of-plane atoms deviating by 0.544?(1) and 0.511?(1)?Å from the plane through the remaining atoms in the ring. Sterically favoured non-H-atom C?O inter-molecular contacts are observed in the structure, within a 3.00?Å range. The crystal packing is stabilized by C-H?O and C-H?F hydrogen bonds and an inter-molecular ?-? inter-action [centroid-centroid separation of 3.783?(1)?Å]. Alternating C-H?O and C-H?F inter-molecular inter-actions generate chains running along the a axis, while a centrosymmetric R(2) (2)(16) ring involving C-H?O inter-actions is formed centred at (1/2, 1/2, 0).

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