Ontology highlight
ABSTRACT:
SUBMITTER: Louie RJ
PROVIDER: S-EPMC2975245 | biostudies-other | 2010 Nov
REPOSITORIES: biostudies-other
Louie Raymond J RJ Pagant Silvere S Youn Ji-Young JY Halliday John J JJ Huyer Gregory G Michaelis Susan S Miller Elizabeth A EA
The Journal of biological chemistry 20100914 46
ATP-binding cassette (ABC) transporters are integral membrane proteins that couple ATP binding/hydrolysis with the transport of hydrophilic substrates across lipid barriers. Deletion of Phe-670 in the first nucleotide-binding domain (NBD1) of the yeast ABC transporter, Yor1p, perturbs interdomain associations, reduces functionality, and hinders proper transport to the plasma membrane. Functionality of Yor1p-ΔF was restored upon co-expression of a peptide containing wild-type NBD1. To gain insigh ...[more]