Ontology highlight
ABSTRACT:
SUBMITTER: Goodman AL
PROVIDER: S-EPMC2976338 | biostudies-other | 2010 Nov
REPOSITORIES: biostudies-other
Goodman Anna L AL Epp C C Moss D D Holder A A AA Wilson J M JM Gao G P GP Long C A CA Remarque E J EJ Thomas A W AW Ammendola V V Colloca S S Dicks M D J MD Biswas S S Seibel D D van Duivenvoorde L M LM Gilbert S C SC Hill A V S AV Draper S J SJ
Infection and immunity 20100816 11
Although merozoite surface protein 1 (MSP-1) is a leading candidate vaccine antigen for blood-stage malaria, its efficacy in clinical trials has been limited in part by antigenic polymorphism and potentially by the inability of protein-in-adjuvant vaccines to induce strong cellular immunity. Here we report the design of novel vectored Plasmodium falciparum vaccines capable of overcoming such limitations. We optimized an antigenic insert comprising the four conserved blocks of MSP-1 fused to tand ...[more]