Host cell invasion and virulence mediated by Candida albicans Ssa1.
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ABSTRACT:
SUBMITTER: Sun JN
PROVIDER: S-EPMC2978716 | biostudies-other | 2010 Nov
REPOSITORIES: biostudies-other
Publications
Host cell invasion and virulence mediated by Candida albicans Ssa1.
Sun Jianing N JN Solis Norma V NV Phan Quynh T QT Bajwa Jashanjot S JS Kashleva Helena H Thompson Angela A Liu Yaoping Y Dongari-Bagtzoglou Anna A Edgerton Mira M Filler Scott G SG
PLoS pathogens 20101111 11
Candida albicans Ssa1 and Ssa2 are members of the HSP70 family of heat shock proteins that are expressed on the cell surface and function as receptors for antimicrobial peptides such as histatins. We investigated the role of Ssa1 and Ssa2 in mediating pathogenic host cell interactions and virulence. A C. albicans ssa1Δ/Δ mutant had attenuated virulence in murine models of disseminated and oropharyngeal candidiasis, whereas an ssa2Δ/Δ mutant did not. In vitro studies revealed that the ssa1Δ/Δ mut ...[more]
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