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Trihexyphenidyl hydro-chloride: a powder diffraction study.

ABSTRACT: IN THE CATION OF THE TITLE COMPOUND [SYSTEMATIC NAME: 1-(3-cyclo-hexyl-3-hy-droxy-3-phenyl-prop-yl)piperidinium chloride], C(20)H(32)NO(+)·Cl(-), the cyclo-hexyl and piperidine rings are in chair conformations. In the crystal structure, cations and anions are linked into chains along the c-axis direction via O-H?Cl and N-H?Cl hydrogen bonds. Weak inter-molecular C-H?Cl inter-actions link further these chains into layers parallel to the bc plane. The salt, obtained from a racemic solution, was found to crystallize in the chiral P2(1)2(1)2 space group, indicating that, in the absence of any evident chirality-inducing process, the polycrystalline powders consist of an equivalent mixture of R and S enanti-omers, forming a racemic conglomerate.

SUBMITTER: Maccaroni E

PROVIDER: S-EPMC2983296 | biostudies-other | 2010

REPOSITORIES: biostudies-other

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Trihexyphenidyl hydro-chloride: a powder diffraction study.

Maccaroni Elisabetta E Malpezzi Luciana L Masciocchi Norberto N

Acta crystallographica. Section E, Structure reports online 20100904 Pt 10

IN THE CATION OF THE TITLE COMPOUND [SYSTEMATIC NAME: 1-(3-cyclo-hexyl-3-hy-droxy-3-phenyl-prop-yl)piperidinium chloride], C(20)H(32)NO(+)·Cl(-), the cyclo-hexyl and piperidine rings are in chair conformations. In the crystal structure, cations and anions are linked into chains along the c-axis direction via O-H⋯Cl and N-H⋯Cl hydrogen bonds. Weak inter-molecular C-H⋯Cl inter-actions link further these chains into layers parallel to the bc plane. The salt, obtained from a racemic solution, was fo ...[more]

PMID: 21587506

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