Ontology highlight
ABSTRACT:
SUBMITTER: Martin AC
PROVIDER: S-EPMC298475 | biostudies-other | 1989 Dec
REPOSITORIES: biostudies-other
Martin A C AC Cheetham J C JC Rees A R AR
Proceedings of the National Academy of Sciences of the United States of America 19891201 23
To be of any value, a predicted model of an antibody combining site should have an accuracy approaching that of antibody structures determined by x-ray crystallography (1.6-2.7 A). A number of modeling protocols have been proposed, which fall into two main categories--those that adopt a knowledge-based approach and those that attempt to construct the hypervariable loop regions of the antibody ab initio. Here we present a combined algorithm requiring no arbitrary decisions on the part of the user ...[more]