Ontology highlight
ABSTRACT:
SUBMITTER: Gompf HS
PROVIDER: S-EPMC2989851 | biostudies-other | 2010 Oct
REPOSITORIES: biostudies-other
Gompf Heinrich S HS Mathai Christine C Fuller Patrick M PM Wood David A DA Pedersen Nigel P NP Saper Clifford B CB Lu Jun J
The Journal of neuroscience : the official journal of the Society for Neuroscience 20101001 43
Locus ceruleus (LC) neuronal activity is correlated with the waking state, yet LC lesions produce only minor alterations in daily wakefulness. Here, we report that sustained elevations in neurobehavioral and EEG arousal in response to exposure to an environment with novel stimuli, including social interaction, are prevented by selective chemical lesions of the LC in rats. Similar results are seen when the anterior cingulate cortex (ACC), which receives especially dense LC innervation, is selecti ...[more]