Ontology highlight
ABSTRACT:
SUBMITTER: Chakraborty D
PROVIDER: S-EPMC2989890 | biostudies-other | 2010 Dec
REPOSITORIES: biostudies-other
Chakraborty Dibyendu D Conley Shannon M SM Stuck Michael W MW Naash Muna I MI
Human molecular genetics 20100921 24
Cysteine 150 of retinal degeneration slow protein (RDS) mediates the intermolecular disulfide bonding necessary for large RDS complex assembly and morphogenesis of the rim region of photoreceptor outer segments. Previously, we showed that cones have a different requirement for RDS than rods, but the nature of that difference was unclear. Here, we express oligomerization-incompetent RDS (C150S-RDS) in the cone-dominant nrl(-/-) mouse. Expression of C150S-RDS leads to dominant functional abnormali ...[more]