Ontology highlight
ABSTRACT:
SUBMITTER: Aldhous MC
PROVIDER: S-EPMC2989891 | biostudies-other | 2010 Dec
REPOSITORIES: biostudies-other
Aldhous Marian C MC Abu Bakar Suhaili S Prescott Natalie J NJ Palla Raquel R Soo Kimberley K Mansfield John C JC Mathew Christopher G CG Satsangi Jack J Armour John A L JA
Human molecular genetics 20100921 24
The copy number variation in beta-defensin genes on human chromosome 8 has been proposed to underlie susceptibility to inflammatory disorders, but presents considerable challenges for accurate typing on the scale required for adequately powered case-control studies. In this work, we have used accurate methods of copy number typing based on the paralogue ratio test (PRT) to assess beta-defensin copy number in more than 1500 UK DNA samples including more than 1000 cases of Crohn's disease. A subse ...[more]