Ontology highlight
ABSTRACT:
SUBMITTER: DeConti RC
PROVIDER: S-EPMC2990578 | biostudies-other | 2010 Nov
REPOSITORIES: biostudies-other
DeConti R C RC Algazi A P AP Andrews S S Urbas P P Born O O Stoeckigt D D Floren L L Hwang J J Weber J J Sondak V K VK Daud A I AI
British journal of cancer 20101005 10
<h4>Background</h4>Sagopilone is a novel fully synthetic epothilone with promising preclinical activity and a favourable toxicity profile in phase I testing.<h4>Methods</h4>A phase II pharmacokinetic and efficacy trial was conducted in patients with metastatic melanoma. Patients had measurable disease, Eastern Cooperative Oncology Group performance status 0-2, adequate haematological, and organ function, with up to 2 previous chemotherapy and any previous immunotherapy regimens. Sagopilone, 16 m ...[more]