Ontology highlight
ABSTRACT:
SUBMITTER: Dorier J
PROVIDER: S-EPMC2995080 | biostudies-other | 2010 Nov
REPOSITORIES: biostudies-other
Nucleic acids research 20100731 21
Using numerical simulations, we investigate the underlying physical effects responsible for the overall organization of chromosomal territories in interphase nuclei. In particular, we address the following three questions: (i) why are chromosomal territories with relatively high transcriptional activity on average, closer to the centre of cell's nucleus than those with the lower activity? (ii) Why are actively transcribed genes usually located at the periphery of their chromosomal territories? ( ...[more]