Ontology highlight
ABSTRACT:
SUBMITTER: Wei J
PROVIDER: S-EPMC2995802 | biostudies-other | 2010
REPOSITORIES: biostudies-other
Wei Junxia J Zhao Jiang J Long Min M Han Yuan Y Wang Xi X Lin Fang F Ren Jihong J He Ting T Zhang Huizhong H
BMC cancer 20101119
<h4>Background</h4>Non-small-cell lung carcinomas (NSCLCs) exhibit poor prognosis and are usually resistant to conventional chemotherapy. Absence of p21WAF1/CIP1, a cyclin-dependent kinase (cdk) inhibitor, has been linked to drug resistance in many in vitro cellular models. RNA activation (RNAa) is a transcriptional activation phenomena guided by double-strand RNA (dsRNA) targeting promoter region of target gene.<h4>Methods</h4>In this study, we explored the effect of up-regulation of p21 gene e ...[more]