Ontology highlight
ABSTRACT:
SUBMITTER: Tong Y
PROVIDER: S-EPMC2996657 | biostudies-other | 2010 Nov
REPOSITORIES: biostudies-other
Tong Yufeng Y Tempel Wolfram W Wang Hui H Yamada Kaori K Shen Limin L Senisterra Guillermo A GA MacKenzie Farrell F Chishti Athar H AH Park Hee-Won HW
Proceedings of the National Academy of Sciences of the United States of America 20101105 47
Phosphatidylinositol 3,4,5-triphosphate (PIP3) plays a key role in neuronal polarization and axon formation. PIP3-containing vesicles are transported to axon tips by the kinesin KIF13B via an adaptor protein, centaurin α1 (CENTA1). KIF13B interacts with CENTA1 through its forkhead-associated (FHA) domain. We solved the crystal structures of CENTA1 in ligand-free, KIF13B-FHA domain-bound, and PIP3 head group (IP4)-bound conformations, and the CENTA1/KIF13B-FHA/IP4 ternary complex. The first pleck ...[more]