Traf7, a MyoD1 transcriptional target, regulates nuclear factor-?B activity during myogenesis.
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ABSTRACT:
SUBMITTER: Tsikitis M
PROVIDER: S-EPMC2999857 | biostudies-other | 2010 Dec
REPOSITORIES: biostudies-other
Publications
Traf7, a MyoD1 transcriptional target, regulates nuclear factor-κB activity during myogenesis.
Tsikitis Mary M Acosta-Alvear Diego D Blais Alexandre A Campos Eric I EI Lane William S WS Sánchez Irma I Dynlacht Brian D BD
EMBO reports 20101015 12
We have identified the E3 ligase Traf7 as a direct MyoD1 target and show that cell cycle exit-an early event in muscle differentiation-is linked to decreased Traf7 expression. Depletion of Traf7 accelerates myogenesis, in part through downregulation of nuclear factor-κB (NF-κB) activity. We used a proteomic screen to identify NEMO, the NF-κB essential modulator, as a Traf7-interacting protein. Finally, we show that ubiquitylation of NF-κB essential modulator is regulated exclusively by Traf7 act ...[more]
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