The Ste20 kinase misshapen is essential for the invasive behaviour of ovarian epithelial cells in Drosophila.
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ABSTRACT:
SUBMITTER: Cobreros-Reguera L
PROVIDER: S-EPMC2999858 | biostudies-other | 2010 Dec
REPOSITORIES: biostudies-other
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The Ste20 kinase misshapen is essential for the invasive behaviour of ovarian epithelial cells in Drosophila.
Cobreros-Reguera Laura L Fernández-Miñán Ana A Fernández-Espartero Cecilia H CH López-Schier Hernán H González-Reyes Acaimo A Martín-Bermudo María D MD
EMBO reports 20101112 12
Stationary-to-migratory transitions of epithelial cells have a key role in development and tumour progression. Border cell migration is a powerful system in which to investigate this transition in living organisms. Here, we identify the Ste20-like kinase misshapen (msn) as a novel regulator of border-cell migration in Drosophila. Expression of msn in border cells is independent of the transcription factor slow border cells and of inputs from all pathways that are known to control border-cell mig ...[more]
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