Ontology highlight
ABSTRACT:
SUBMITTER: Qu Y
PROVIDER: S-EPMC3007146 | biostudies-other | 2011 Jan
REPOSITORIES: biostudies-other
Qu Ying Y Wang Jinhua J Ray Partha S PS Guo Hua H Huang Jian J Shin-Sim Miyung M Bukoye Bolanle A BA Liu Bingya B Lee Adrian V AV Lin Xin X Huang Peng P Martens John W JW Giuliano Armando E AE Zhang Ning N Cheng Ning-Hui NH Cui Xiaojiang X
The Journal of clinical investigation 20101201 1
Cancer cells have an efficient antioxidant system to counteract their increased generation of ROS. However, whether this ability to survive high levels of ROS has an important role in the growth and metastasis of tumors is not well understood. Here, we demonstrate that the redox protein thioredoxin-like 2 (TXNL2) regulates the growth and metastasis of human breast cancer cells through a redox signaling mechanism. TXNL2 was found to be overexpressed in human cancers, including breast cancers. Kno ...[more]