Thalamocortical model for a propofol-induced alpha-rhythm associated with loss of consciousness.
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ABSTRACT:
SUBMITTER: Ching S
PROVIDER: S-EPMC3012501 | biostudies-other | 2010 Dec
REPOSITORIES: biostudies-other
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Thalamocortical model for a propofol-induced alpha-rhythm associated with loss of consciousness.
Ching Shinung S Cimenser Aylin A Purdon Patrick L PL Brown Emery N EN Kopell Nancy J NJ
Proceedings of the National Academy of Sciences of the United States of America 20101213 52
Recent data reveal that the general anesthetic propofol gives rise to a frontal α-rhythm at dose levels sufficient to induce loss of consciousness. In this work, a computational model is developed that suggests the network mechanisms responsible for such a rhythm. It is shown that propofol can alter the dynamics in thalamocortical loops, leading to persistent and synchronous α-activity. The synchrony that forms in the cortex by virtue of the involvement of the thalamus may impede responsiveness ...[more]
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