Ontology highlight
ABSTRACT:
SUBMITTER: Chen T
PROVIDER: S-EPMC3014451 | biostudies-other | 2011 Jan
REPOSITORIES: biostudies-other
Chen Tian T Benmohamed Radhia R Arvanites Anthony C AC Ralay Ranaivo Hantamalala H Morimoto Richard I RI Ferrante Robert J RJ Watterson D Martin DM Kirsch Donald R DR Silverman Richard B RB
Bioorganic & medicinal chemistry 20101030 1
Amyotrophic lateral sclerosis (ALS) is an orphan neurodegenerative disease currently without a cure. Mutations in copper/zinc superoxide dismutase 1 (SOD1) have been implicated in the pathophysiology of this disease. Using a high-throughput screening assay expressing mutant G93A SOD1, two bioactive chemical hit compounds (1 and 2), identified as arylsulfanyl pyrazolones, were identified. The structural optimization of this scaffold led to the generation of a more potent analogue (19) with an EC( ...[more]