Ontology highlight
ABSTRACT:
SUBMITTER: van Heeringen SJ
PROVIDER: S-EPMC3018809 | biostudies-other | 2011 Jan
REPOSITORIES: biostudies-other
van Heeringen Simon J SJ Veenstra Gert Jan C GJ
Bioinformatics (Oxford, England) 20101115 2
<h4>Summary</h4>Accurate prediction of transcription factor binding motifs that are enriched in a collection of sequences remains a computational challenge. Here we report on GimmeMotifs, a pipeline that incorporates an ensemble of computational tools to predict motifs de novo from ChIP-sequencing (ChIP-seq) data. Similar redundant motifs are compared using the weighted information content (WIC) similarity score and clustered using an iterative procedure. A comprehensive output report is generat ...[more]