Analyzing marginal cases in differential shotgun proteomics.
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ABSTRACT:
SUBMITTER: Carvalho PC
PROVIDER: S-EPMC3018820 | biostudies-other | 2011 Jan
REPOSITORIES: biostudies-other
Publications
Analyzing marginal cases in differential shotgun proteomics.
Carvalho Paulo C PC Fischer Juliana S G JS Perales Jonas J Yates John R JR Barbosa Valmir C VC Bareinboim Elias E
Bioinformatics (Oxford, England) 20101111 2
<h4>Summary</h4>We present an approach to statistically pinpoint differentially expressed proteins that have quantitation values near the quantitation threshold and are not identified in all replicates (marginal cases). Our method uses a Bayesian strategy to combine parametric statistics with an empirical distribution built from the reproducibility quality of the technical replicates.<h4>Availability</h4>The software is freely available for academic use at http://pcarvalho.com/patternlab. ...[more]
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