Analyzing marginal cases in differential shotgun proteomics.

ABSTRACT: We present an approach to statistically pinpoint differentially expressed proteins that have quantitation values near the quantitation threshold and are not identified in all replicates (marginal cases). Our method uses a Bayesian strategy to combine parametric statistics with an empirical distribution built from the reproducibility quality of the technical replicates.The software is freely available for academic use at http://pcarvalho.com/patternlab.

SUBMITTER: Carvalho PC 

PROVIDER: S-EPMC3018820 | biostudies-other | 2011 Jan

REPOSITORIES: biostudies-other