Ryanodine receptor-2 upregulation and nicotine-mediated plasticity.
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ABSTRACT:
SUBMITTER: Ziviani E
PROVIDER: S-EPMC3020107 | biostudies-other | 2011 Jan
REPOSITORIES: biostudies-other
Publications
Ryanodine receptor-2 upregulation and nicotine-mediated plasticity.
Ziviani Elena E Lippi Giordano G Bano Daniele D Munarriz Eliana E Guiducci Stefania S Zoli Michele M Young Kenneth W KW Nicotera Pierluigi P
The EMBO journal 20101126 1
Nicotine, the major psychoactive component of cigarette smoke, modulates neuronal activity to produce Ca2+-dependent changes in gene transcription. However, the downstream targets that underlie the long-term effects of nicotine on neuronal function, and hence behaviour, remain to be elucidated. Here, we demonstrate that nicotine administration to mice upregulates levels of the type 2 ryanodine receptor (RyR2), a Ca2+-release channel present on the endoplasmic reticulum, in a number of brain area ...[more]
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2020-01-18 | GSE143854 | GEO
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