Ontology highlight
ABSTRACT:
SUBMITTER: Kanegae Y
PROVIDER: S-EPMC3025582 | biostudies-other | 2011 Jan
REPOSITORIES: biostudies-other
Kanegae Yumi Y Terashima Miho M Kondo Saki S Fukuda Hiromitsu H Maekawa Aya A Pei Zheng Z Saito Izumu I
Nucleic acids research 20101104 2
Tissue-/cancer-specific promoters for use in adenovirus vectors (AdVs) are valuable for elucidating specific gene functions and for use in gene therapy. However, low activity, non-specific expression and size limitations in the vector are always problems. Here, we developed a 'double-unit' AdV containing the Cre gene under the control of an α-fetoprotein promoter near the right end of its genome and bearing a compact 'excisional-expression' unit consisting of a target cDNA 'upstream' of a potent ...[more]