The recombinase IntA is required for excision of esp-containing ICEEfm1 in Enterococcus faecium.
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SUBMITTER: Top J
PROVIDER: S-EPMC3028673 | biostudies-other | 2011 Feb
REPOSITORIES: biostudies-other
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The recombinase IntA is required for excision of esp-containing ICEEfm1 in Enterococcus faecium.
Top Janetta J Sinnige Jan C JC Majoor Eline A M EA Bonten Marc J M MJ Willems Rob J L RJ van Schaik Willem W
Journal of bacteriology 20101210 4
Comparative genome analysis of Enterococcus faecium recently revealed that a genomic island containing the esp gene, referred to as the esp-containing pathogenicity island (esp PAI), can be transferred by conjugation and contains a partial Tn916-like element and an integrase gene, intA. Here, we characterize the role of intA in the excision of the esp PAI. An intA insertion-deletion mutant in E. faecium E1162 (E1162ΔintA) was constructed and in trans complemented with wild-type intA (E1162ΔintA: ...[more]
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