Ontology highlight
ABSTRACT:
SUBMITTER: Chudasama SL
PROVIDER: S-EPMC3031390 | biostudies-other | 2010 Dec
REPOSITORIES: biostudies-other
Chudasama Shalini L SL Espinasse Benjamin B Hwang Fred F Qi Rui R Joglekar Manali M Afonina Galyna G Wiesner Mark R MR Welsby Ian J IJ Ortel Thomas L TL Arepally Gowthami M GM
Blood 20100917 26
The immune response in heparin-induced thrombocytopenia is initiated by and directed to large multimolecular complexes of platelet factor 4 (PF4) and heparin (H). We have previously shown that PF4:H multimolecular complexes assemble through electrostatic interactions and, once formed, are highly immunogenic in vivo. Based on these observations, we hypothesized that other positively charged proteins would exhibit similar biologic interactions with H. To test this hypothesis, we selected 2 unrelat ...[more]