Identification of hifD and hifE in the pilus gene cluster of Haemophilus influenzae type b strain Eagan.
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ABSTRACT:
SUBMITTER: McCrea KW
PROVIDER: S-EPMC303208 | biostudies-other | 1994 Nov
REPOSITORIES: biostudies-other
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Identification of hifD and hifE in the pilus gene cluster of Haemophilus influenzae type b strain Eagan.
McCrea K W KW Watson W J WJ Gilsdorf J R JR Marrs C F CF
Infection and immunity 19941101 11
Haemophilus influenzae produces surface structures called pili that promote adherence to human cells. Three genes encoding the major pilus structural component (pilin), chaperone, and usher proteins (designated hifA, -B, and -C, respectively) have been identified previously. In this study, transposon mutagenesis and DNA sequence analysis identified two open reading frames (ORFs) downstream of, and in the same orientation as, hifC. These genes have been designated hifD and hifE. Both genes have p ...[more]
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