Ontology highlight
ABSTRACT:
SUBMITTER: Knight MJ
PROVIDER: S-EPMC3035719 | biostudies-other | 2010 Nov
REPOSITORIES: biostudies-other
Knight Mary Jane MJ Joubert Marisa K MK Plotkowski Megan L ML Kropat Janette J Gingery Mari M Sakane Fumio F Merchant Sabeeha S SS Bowie James U JU
Biochemistry 20101101 44
The diacylglycerol kinase (DGK) family of enzymes plays critical roles in lipid signaling pathways by converting diacylglycerol to phosphatidic acid, thereby downregulating signaling by the former and upregulating signaling by the latter second messenger. Ten DGK family isozymes have been identified to date, which possess different interaction motifs imparting distinct temporal and spatial control of DGK activity to each isozyme. Two DGK family members, δ and η, contain a sterile alpha motif (SA ...[more]