Cell shape and substrate rigidity both regulate cell stiffness.
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ABSTRACT:
SUBMITTER: Tee SY
PROVIDER: S-EPMC3043219 | biostudies-other | 2011 Mar
REPOSITORIES: biostudies-other
Publications
Cell shape and substrate rigidity both regulate cell stiffness.
Tee Shang-You SY Fu Jianping J Chen Christopher S CS Janmey Paul A PA
Biophysical journal 20110301 5
Cells from many different tissues sense the stiffness and spatial patterning of their microenvironment to modulate their shape and cortical stiffness. It is currently unknown how substrate stiffness, cell shape, and cell stiffness modulate or interact with one another. Here, we use microcontact printing and microfabricated arrays of elastomeric posts to independently and simultaneously control cell shape and substrate stiffness. Our experiments show that cell cortical stiffness increases as a fu ...[more]
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