Ontology highlight
ABSTRACT:
SUBMITTER: Li H
PROVIDER: S-EPMC3048183 | biostudies-other | 2011 Mar
REPOSITORIES: biostudies-other
Molecular therapy : the journal of the American Society of Gene Therapy 20101214 3
Using adoptive transfer models we determined that an adeno-associated viral vector of serotype 2 (AAV2) induces in mice proliferation of CD8(+) T cells that recognize an epitope within the viral capsid. Proliferation to an endogenous epitope within viral protein (VP)3 could be observed for at least 3 weeks while a foreign epitope placed at multiple copies within VP2 elicited CD8(+) T cell expansion for at least 10 weeks. These data show that capsid antigens of AAV2 degrade slowly over a period o ...[more]