Adeno-associated virus vectors serotype 2 induce prolonged proliferation of capsid-specific CD8+ T cells in mice.
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ABSTRACT:
SUBMITTER: Li H
PROVIDER: S-EPMC3048183 | biostudies-other | 2011 Mar
REPOSITORIES: biostudies-other
Publications
Adeno-associated virus vectors serotype 2 induce prolonged proliferation of capsid-specific CD8+ T cells in mice.
Li Hua H Tuyishime Steven S Wu Te-Lang TL Giles-Davis Wynetta W Zhou Dongming D Xiao Weidong W High Katherine A KA Ertl Hildegund C J HC
Molecular therapy : the journal of the American Society of Gene Therapy 20101214 3
Using adoptive transfer models we determined that an adeno-associated viral vector of serotype 2 (AAV2) induces in mice proliferation of CD8(+) T cells that recognize an epitope within the viral capsid. Proliferation to an endogenous epitope within viral protein (VP)3 could be observed for at least 3 weeks while a foreign epitope placed at multiple copies within VP2 elicited CD8(+) T cell expansion for at least 10 weeks. These data show that capsid antigens of AAV2 degrade slowly over a period o ...[more]
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