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Treatment of severe metastatic calcification and calciphylaxis in dialysis patients.


ABSTRACT: Metastatic calcification is a frequent complication encountered in patients undergoing maintenance dialysis and has a complex pathogenesis. It is often difficult to treat and is associated with high morbidity and mortality. Early recognition and prompt initiation of treatment is vital. Local wound care and aggressive metabolic control remain the cornerstones of the therapy. Various novel treatment strategies including sodium thiosulfate and hyperbaric oxygen therapy have been utilized and reviewed in this paper. The response rate to treatment is poor and prevention is the best approach.

SUBMITTER: Goel SK 

PROVIDER: S-EPMC3056381 | biostudies-other | 2011 Feb

REPOSITORIES: biostudies-other

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Treatment of severe metastatic calcification and calciphylaxis in dialysis patients.

Goel Saurabh K SK   Bellovich Keith K   McCullough Peter A PA  

International journal of nephrology 20110224


Metastatic calcification is a frequent complication encountered in patients undergoing maintenance dialysis and has a complex pathogenesis. It is often difficult to treat and is associated with high morbidity and mortality. Early recognition and prompt initiation of treatment is vital. Local wound care and aggressive metabolic control remain the cornerstones of the therapy. Various novel treatment strategies including sodium thiosulfate and hyperbaric oxygen therapy have been utilized and review  ...[more]

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