Ontology highlight
ABSTRACT:
SUBMITTER: Andreadis A
PROVIDER: S-EPMC307241 | biostudies-other | 1995 Sep
REPOSITORIES: biostudies-other
Andreadis A A Broderick J A JA Kosik K S KS
Nucleic acids research 19950901 17
Tau is a microtubule-associated protein whose transcript undergoes complex regulated splicing in the mammalian nervous system. Exons 2 and 3 of the gene are alternatively spliced cassettes in which exon 3 never appears independently of exon 2. Expression of tau minigene constructs in cells indicate that exon 2 resembles a constitutive exon, while a suboptimal branch point connected to exon 3 inhibits inclusion of exon 3 in the mRNA. Splicing of the two tau exons is controlled by their relative a ...[more]