Ontology highlight
ABSTRACT:
SUBMITTER: Fu X
PROVIDER: S-EPMC3076848 | biostudies-other | 2011 Apr
REPOSITORIES: biostudies-other
Fu Xing X Giavalisco Patrick P Liu Xiling X Catchpole Gareth G Fu Ning N Ning Zhi-Bin ZB Guo Song S Yan Zheng Z Somel Mehmet M Pääbo Svante S Zeng Rong R Willmitzer Lothar L Khaitovich Philipp P
Proceedings of the National Academy of Sciences of the United States of America 20110328 15
Human evolution is characterized by the rapid expansion of brain size and drastic increase in cognitive capabilities. It has long been suggested that these changes were accompanied by modifications of brain metabolism. Indeed, human-specific changes on gene expression or amino acid sequence were reported for a number of metabolic genes, but actual metabolite measurements in humans and apes have remained scarce. Here, we investigate concentrations of more than 100 metabolites in the prefrontal an ...[more]